Targeted diphtheria toxin to treat BPDCN
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چکیده
منابع مشابه
Hypersensitivity to diphtheria toxin by mouse cells expressing both diphtheria toxin receptor and CD9 antigen.
DTS-II is a highly diphtheria toxin (DT)-sensitive cell line previously isolated by transfection of wild-type DT-resistant mouse L-M(TK-) cells with the cDNA encoding a monkey Vero cell DT receptor. DTS-II cells are as toxin-sensitive as Vero cells, have approximately 3-fold more receptors than Vero cells, and have approximately 10-fold lower affinity for DT than Vero cells. We now cotransfecte...
متن کاملCharacteristics of human antibody to diphtheria toxin.
Human antibody to diphtheria toxin was analyzed with an ammonium sulfate radioimmunoassay. In 15 immune sera with titers of between 0.03 and 25 units/ml, the avidity was similar to that of U.S. standard antitoxin. The proportion of the post-immunization anti-diphtheria antibody specific for fragment A was variable, but in the 10 sera tested constituted a substantial fraction of the antibody. Ap...
متن کاملDiphtheria Toxin In
Recent studies have demonstrated that diphtheria toxin is an enzyme of unusual type. Small amounts of the toxin, added to nicotinamide adenine dinucleotide (NAD)-containing mammalian cell extracts, block peptide-bond formation by catalyzing inactivation of the translocating enzyme, aminoacyltransferase 2 (T2) (1-3). This highly specific reaction involves the splitting of NAD with liberation of ...
متن کاملPotency of a Human Monoclonal Antibody to Diphtheria Toxin Relative to Equine Diphtheria Anti-toxin in an Animal Model
116. Potency of a Human Monoclonal Antibody to Diphtheria Toxin Relative to Equine Diphtheria Anti-toxin in an Animal Model Heidi Smith, MD, PhD; Peter Cheslock, PhD; Mark Leney, PhD; Bruce Barton, PhD; Deborah Molrine, MD; MassBiologics of the University of Massachusetts Medical School, Boston, Massachusetts; Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, ...
متن کاملThe Production of Diphtheria Toxin
Toxin of sufficient strength to kill a 400-gramme guinea-pig in three days and a half in a dose of 0.cubic centimetre developed in suitable bouillon, contained in ordinary Erlenmeyer flasks, within a period of twenty-four hours. In such boullon the toxin reached its greatest strength in from four to seven days (0.005 cubic centimetre killing a 500-gramme guinea-pig in three days). This period o...
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ژورنال
عنوان ژورنال: Blood
سال: 2014
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2014-06-578633